Case Of The Month - July 2005
Introduction
This month's case has been kindly put together by Nirup Kumar of DML. There are 6 images and the "answer" with histology will be submitted next month
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Clinical History
- 37 year old
- Routine Cervical Smear
- No history
- Has had regular smears
Image 1
Image 2
Image 3
Image 4
Image 5
Image 6
Diagnosis
Poorly differentiated carcinoma (Glassy Cell Carcinoma) of the cervix.
Glassy Cell Carcinoma
This is highly aggressive, undifferentiated form of adenosquamous carcinoma and accounts for 20% of adenosquamous carcinoma.
Cytologic Characteristics:
- Cells show abundant finely granular or "ground" glass" cytoplasm.
- Nuclei is round with prominent large, sometimes multiple nucleoli.
- Cells may contain glycogen and eosinophils may be present.
Histologic Characteristics:
(See images 7 and 8 below)
- Nests and sheets of large cells are present.
- Cytoplasm is abundant, eosinophilic-amophilic with a finely granular or "ground glass" appearance. Cells show prominent cell borders.
- Nucleoli is large with prominent nucleoli.
- There is often stromal inflammatory infiltrate composed predominantly of eosinophils and plasma cells.
Conclusion: Poor Prognosis
Image 7 - H and E
Image 8 - H and E
Thanks to Nirup for submitting this case